Synthesis, antitumor and antibacterial activity of some Ru(bpy)2+2/4-substituted thiosemicarbazide complexes
U K Mazumder*, Malaya Gupta, A Bera, S Bhattacharya, S Karki, L Manikandan & S Patra
Complexes of N-substituted thiosemicarbazides with Ru(II)-2,2 bipyridyl have been prepared and characterised by IR, 1H NMR and UV/Vis spectroscopy in addition to their elemental analysis. Based on molecular mechanics simulations using HyperChem®, the complexes are designed for anticancer activity against Ehrlisch Ascites Carcinoma. Their effects on the hematological profile of the tumor hosts have also been studied. The complexes are found to possess prominent antibacterial activity.
Indian Journal of Chemistry
Vol. 42A, February 2003, pp 318-321
U K Mazumder*, Malaya Gupta, A Bera, S Bhattacharya, S Karki, L Manikandan & S Patra
Complexes of N-substituted thiosemicarbazides with Ru(II)-2,2 bipyridyl have been prepared and characterised by IR, 1H NMR and UV/Vis spectroscopy in addition to their elemental analysis. Based on molecular mechanics simulations using HyperChem®, the complexes are designed for anticancer activity against Ehrlisch Ascites Carcinoma. Their effects on the hematological profile of the tumor hosts have also been studied. The complexes are found to possess prominent antibacterial activity.
Indian Journal of Chemistry
Vol. 42A, February 2003, pp 318-321
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