Preservatives are substances that commonly added to various foods and pharmaceutical products in order to prolong their shelf life. The addition of preservatives to such products, especially to those that have higher water content, is essential for avoiding alteration and degradation by microorganisms during storage 1-3 .
Other ingredients are also utilized in preparing the desired dosage form of a drug substance. Some of these agents may be used to achieve the desired physical and chemical characteristics of the product or to improve its appearance, odor and taste. In each instant, the added ingredient must be harmless in the amount used; does not exceed the minimum quantity required to provide its intended effect; its presence does not impair the bioavailability, the therapeutic efficacy or safety of the official preparation, and does not interfere with analysis and tests prescribed for determining compliance with the pharmacopeias standards 4 .
Other ingredients are also utilized in preparing the desired dosage form of a drug substance. Some of these agents may be used to achieve the desired physical and chemical characteristics of the product or to improve its appearance, odor and taste. In each instant, the added ingredient must be harmless in the amount used; does not exceed the minimum quantity required to provide its intended effect; its presence does not impair the bioavailability, the therapeutic efficacy or safety of the official preparation, and does not interfere with analysis and tests prescribed for determining compliance with the pharmacopeias standards 4 .
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