Chemical speciation and biological activity of bivalent metal complexes of polydentate amide ligands
Bhagwan Singh Garg*, Meenu Sarbhai & Deo Nandan Kumar
Stability constants of N,N-bis-(3-carboxy-1-oxopropanyl)-1,2-ethylenediamine(L1), N,N-bis-(3-carboxy-1-oxopropanyl)-1,2-phenylenediamine(L2), N,N-bis-(2-carboxy-1-oxophenelenyl)-1,2-phenylenediamine(L3) have been determined in aqueous medium (for L1 & L2) and 75% (v/v) methanol-water medium for L3 pH-metrically. The formation constants (logn) have been calculated using the Bjerrum half integral method and weighted least squares method. Species distribution curves of complexes have been plotted as a function of pH which shows at lower pH values 1:1 complexes are formed and 1:2 complexes are formed at neutral or higher pH. The biological study indicates that ligands and their complexes are better fungicidal than bactericidal. Copper complexes of all the ligands showed potential antifungal and antibacterial activities. Ligand L3 and its copper(II) complexes are most effective against A. niger, E. coli and S. aureus
Indian Journal of Chemistry
Vol. 42A, February 2003, pp 280-286
Bhagwan Singh Garg*, Meenu Sarbhai & Deo Nandan Kumar
Stability constants of N,N-bis-(3-carboxy-1-oxopropanyl)-1,2-ethylenediamine(L1), N,N-bis-(3-carboxy-1-oxopropanyl)-1,2-phenylenediamine(L2), N,N-bis-(2-carboxy-1-oxophenelenyl)-1,2-phenylenediamine(L3) have been determined in aqueous medium (for L1 & L2) and 75% (v/v) methanol-water medium for L3 pH-metrically. The formation constants (logn) have been calculated using the Bjerrum half integral method and weighted least squares method. Species distribution curves of complexes have been plotted as a function of pH which shows at lower pH values 1:1 complexes are formed and 1:2 complexes are formed at neutral or higher pH. The biological study indicates that ligands and their complexes are better fungicidal than bactericidal. Copper complexes of all the ligands showed potential antifungal and antibacterial activities. Ligand L3 and its copper(II) complexes are most effective against A. niger, E. coli and S. aureus
Indian Journal of Chemistry
Vol. 42A, February 2003, pp 280-286
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